Dr. Robert M. Friedlander Labpage

   Neuroapoptosis Laboratory  

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Stavrovskaya IG, Narayanan MV, Zhang W, Krasnikov BF, Heemskerk J, Young SS, Blass JP, Brown AM, Beal MF, Friedlander RM, Kristal BS. Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology.
J Exp Med. 2004 Jul 19;200(2):211-22.  [Abstract] [PDF]

Zhu S, Li M, Figueroa BE, Liu A, Stavrovskaya IG, Pasinelli P, Beal MF, Brown RH Jr, Kristal BS, Ferrante RJ, Friedlander RM.  Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice.
J Neurosci.J Neurosci. 2004 Jun 30;24(26):5909-12.[Abstract] [PDF]

Teng YD, Choi H, Onario RC, Zhu S, Desilets FC, Lan S, Woodard EJ, Snyder EY, Eichler ME, Friedlander RM.
Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3071-6. [ Abstract] [PDF]

Zhang Y, Ona VO, Li M, Drozda M, Dubois-Dauphin M, Przedborski S, Ferrante RJ, Friedlander RM.   Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease.   
 J Neurochem. 2003 Dec; 87(5): 1184-92.[Abstract] [PDF]

Zhang WH, Wang X, Narayanan M, Zhang Y, Huo C, Reed JC, Friedlander RM. Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death.
Proc Natl Acad Sci . 2003 Dec 23; 100(26): 16012-7. [Abstract] [PDF]

Zhang Y, Li M, Drozda M, Chen M, Ren S, Mejia Sanchez RO, Leavitt BR, Cattaneo E, Ferrante RJ, Hayden MR, Friedlander RM. Depletion of wild-type huntingtin in mouse models of neurologic diseases.
J Neurochem. 2003 Oct; 87(1): 101-6. [Abstract] [PDF]

Wang X, Zhu S, Drozda M, Zhang W, Stavrovskaya IG, Cattaneo E, Ferrante RJ, Kristal BS, Friedlander RM. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease.
Proc Natl Acad Sci. 2003 Sep 2; 100(18): 10483-7. [Abstract] [PDF]

Friedlander RM. Apoptosis and caspases in neurodegenerative diseases.
N Engl J Med.  2003 Apr 3; 348(14): 1365-75. [PDF]

Zhang W, Narayanan M, Friedlander RM. Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS.
Ann Neurol. 2003 Feb; 53(2): 267-70. [Abstract] [PDF]

Guegan C, Vila M, Teismann P, Chen C, Onteniente B, Li M, Friedlander RM, Przedborski S, Teissman P. Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS.
Mol Cell Neurosci. 2002 Aug; 20(4): 553-62. [Abstract] [PDF]

Kiechle T, Dedeoglu A, Kubilus J, Kowall NW, Beal MF, Friedlander RM, Hersch SM, Ferrante RJ. Cytochrome C and caspase-9 expression in Huntington's disease.
Neuromolecular Med. 2002; 1(3): 183-95. [Abstract]

Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration.
 J Neurosci. 2002 May 15; 22(10): 4015-24. [Abstract] [PDF]                                                                                                                                                                                                                                                                          SZhu, Stavrovskaya IG, Drozda M, Kim BYS, Ona V, Li M, Sarang S, Liu AS, Hartley DM, Wu DC, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM   Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice.
Nature 2002 May 2; 417(6884):797-801 [Abstract] [PDF]

Sanchez Mejia RO, Ona VO, Li M, Friedlander RM   Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological disfunction.
Neurosurgery 2001 Jun; 48(6):1393-9 [Abstract]

Li M, Ona VO, Chen M, Kaul M, Tenneti L, Zhang X, Stieg PE, Lipton SA, Friedlander RM   Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury.
Neuroscience 2000 Sept 11; 99(2):333-342 [Abstract]

Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, Hobbs W, Vonsattel JP, Cha JH, Friedlander RM   Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease.
Nature Medicine 2000 Jul; 6(7):797-801 [Abstract][Figure][PDF]

Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH   Neurotoxicity induces cleavage of p35 to p25 by calpain.
Nature 2000 May 18; 405(6784):360-4 [Abstract][PDF]

Li M, Ona VO, Guegan C, Chen M, Jackson-Lewis V, Andrews LJ, Olszewski AJ, Stieg PE, Lee JP, Przedborski S, Friedlander RM   Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model.
Science 2000 Apr 14; 288(5464):335-9 [Abstract][Figure][PDF]

K. B. Fink, L. J. Andrews, W. E. Butler, V. O. Ona,  M. Li,  M. Bogdanov, M. Endres, S. Q. Khan, S. Namura, P.E. Stieg, M. F. Beal, M. A. Moskowitz, J. Yuan, R. M. Friedlander  Reduction of Post-traumatic Brain Injury and Free Radical Production by Inhibition of the Caspase-1 Cascade.
Neuroscience   Nov 1999;  94 (4): 1213-1218  [Abstract]

Ona VO, Li M, Vonsattel JP, Andrews LJ, Khan SQ, Chung WM, Frey AS, Menon AS, Li XJ, Stieg PE, Yuan J, Penney JB, Young AB, Cha JH, Friedlander RM   Inhibition of caspase-1 slows disease progression in a mouse model of Huntington’s disease.
Nature 1999 May 20; 399(6733):263   [Abstract][PDF]

Peter Klevenyi, Ole Andreassen, Robert J. Ferrante, John R. Schleicher Jr, Robert M. Friedlander, M. Flint Beal Clinical Neuroscience: Transgenic mice expressing a dominant negative mutant interleukin-1ß converting enzyme show resistance to MPTP neurotoxicity.
Neuroreport 1999 March; 10(3):635-638

Friedlander RM, Brown RH, Gagliardini V, Wang J, Yuan J Inhibition of ICE slows ALS in mice.
Nature 1997 Jul 3; 388(6637):31 [Abstract][PDF]

Cudkowicz ME, Warren L, Francis JW, Lloyd KJ, Friedlander RM, Borges LF, Kassem N,Munsat TL, Brown RH Jr Intrathecal   administration of recombinant human superoxide dismutase 1 in amyotrophic lateral sclerosis: a preliminary safety and pharmacokinetic study.
Neurology 1997 Jul; 49(1):213-222 [Abstract]

Friedlander RM, Gagliardini V, Hara H, Fink KB, Li W, MacDonald G, Fishman MC, Greenberg AH, Moskowitz MA, Yuan J Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury.
J Exp Med 1997 Mar 3; 185(5):933-940 [Abstract] [PDF]

Hara H, Fink K, Endres M, Friedlander RM, Gagliardini V, Yuan J, Moskowitz MA Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.
J. Cereb Blood Flow Metab 1997 Apr; 17(4):370-375 [Abstract]

Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Huang Z, Shimizu-Sasamata M, Yuan J, Moskowitz MA Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.
Proc Natl Acad Sci U S A 1997 Mar 4; 94(5):2007-2012 [Abstract] [PDF]

Friedlander RM, Gagliardini V, Rotello RJ, Yuan J Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme mediated apoptosis.
J Exp Med 1996 Aug 1; 184(2):717-724  [Abstract]

Miura M, Friedlander RM, Yuan J Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.
Proc Natl Acad Sci U S A 1995 Aug 29; 92(18):8318-8322   [Abstract]